2018/05/22 | North Carolina FC | | 4-1 | | Ocean City Nor´easters | | | | |
2018/05/23 | Richmond Kickers | | 3-2 | | Penn FC | | | | |
| Charleston Battery | | 1-0 | | Elm City Express | | | | |
| Jacksonville Armada | | 0-2 | | Miami United | | | | |
| Pittsburgh Riverhounds | | 1-3 | | FC Cincinnati | | | | |
| Louisville City | | 1-0 | | Saint Louis FC | | | | |
| San Antonio FC | | 1-1 (5-3 Pen.) | | Colorado Springs Switchbacks | | | | |
| Nashville SC | | 3-1 | | Mississippi Brilla | | | | |
| NTX Rayados | | 3-2 | | FC Wichita | | | | |
| Golden State Force | | 2-1 | | Las Vegas Lights | | | | |
| Reno 1868 | | 0-1 | | Sacramento Republic | | | | |
| Sporting Arizona | | 1-2 Pro. | | Fresno FC | | | | |